Derma E Advanced Peptides & Collagen Moisturizer–Hydrate and Smooth Skin with Scientifically Proven Ingredients

One of my favorite skincare products that I tried in 2020 was Acure Radically Rejuvenating Whipped Night Cream. That moisturizer is extremely hydrating and packed full of wonderful skincare ingredients including several peptides which can go a long way in preserving skin’s youthfulness. The one thing I didn’t really care for about it is the extra thick texture which makes it somewhat difficult to blend into the skin and layer with other skincare products. That led me to search for an alternative moisturizer that would provide similar benefits without having such a rich texture. I landed on the Derma E Advanced Peptides & Collagen Moisturizer which I’ve now been using as my night cream for about two or three months.

Derma E Advanced Peptides & Collagen MoisturizerThe most impressive thing about this product (in my opinion) is the multi-peptides. I’m surprised I haven’t seen peptides included in more skincare formulations I’ve reviewed because they are very useful in maintaining skin’s smoothness. There are many types of peptides, but generally they are used to improve skin’s elasticity and reduce wrinkles by producing collagen.

Please continue reading for a full review of this product, including more information about ingredients!

Derma E Advanced Peptides & Collagen Moisturizer product claims directly from

Restores a more youthful appearance to skin by diminishing the look of lines and wrinkles. A highly advanced formulation packed with the peptides and collagen needed for healthy-looking skin makes this the best moisturizer for wrinkles. We use the powerful multi-peptides Matrixyl®synthe’6® and Argireline®, as well as Pycnogenol®, an amazing antioxidant that is thought to support healthy collagen, which is the protein essential for vibrant skin that has a wonderful smoothness and elasticity. With Vitamin C and Green Tea for extra anti-aging antioxidants, the Advanced Peptides and Collagen Moisturizer intensely hydrates while creating a renewed, radiant complexion. 

Disclosure: IntegriBeauty includes affiliate links within product review posts. I receive commissions for purchases made through these links at no additional cost to you. Additionally, as an Amazon Associate I earn from qualifying purchases. IntegriBeauty is independently owned and all products discussed within IntegriBeauty product review posts are thoroughly tested and given honest reviews.

Other product details

  • Price: $21.00 from or $35.00 from
    • ships internationally to over 100 countries, but not all items will ship to every country. Update your default shipping address to see items that will ship to your location.
    • unfortunately only ships within the United States.
  • Net weight: 2 oz. | 56 g
  • Made in the USA
  • Cruelty-free (Leaping Bunny certified)
  • Vegan
  • Free of gluten, soy, parabens, phthalates, formaldehyde, petrolatum, sulfates, mineral oil, artificial color, and artificial fragrance
  • Recyclable packaging
  • Overall rating: 8.8/10
    • Packaging/ease of application: 7/10
    • Hydration: 10/10
    • Team Player: 10/10
    • Ingredients: 7/10
    • Price: 10/10

Please note that I am not a skincare professional. I am simply an individual that enjoys learning about and using skincare products. Speak to your dermatologist or esthetician if you have any concerns.

Packaging/ease of application

This moisturizer is packaged in a nice glass jar with a plastic lid. It’s pretty and feels like a luxury product because of the weight of the glass. Unfortunately, a jar is not the ideal type of packaging for this moisturizer since it contains active ingredients that will degrade more quickly when exposed to light and air. To protect actives’ potency, it’s best for packaging to be opaque and air-restrictive.

The moisturizer itself is very easy to apply. The texture is a bit heavier than the moisturizers I usually use in my morning routine, but more lightweight than a lot of night creams (this is marketed as a moisturizer that can be used in the morning and/or night). It has a very smooth texture that blends into the skin effortlessly. 

One thing about this moisturizer that may make it unpleasant for some to use, is the scent. It has a very strong floral scent, which some people will enjoy while others won’t. As someone that doesn’t usually like floral scents, I wish Derma E had opted not to add any fragrance to this product. However, I don’t notice the floral smell once I’ve had this moisturizer on for a while. 


I purchased this moisturizer to use as my night cream. Since I use lightweight moisturizers in the daytime, I like to use a little bit heavier, very hydrating moisturizers at night. I wasn’t sure exactly what to expect when I ordered the Derma E Advanced Peptides & Collagen Moisturizer, but as I mentioned in the previous section, it actually isn’t very heavy. That isn’t a bad thing, though!

While the texture of this moisturizer is what I’d call “middle of the road,” I still find it to be very hydrating. It quenches my skin’s thirst without making it feel greasy. I’ve actually found that I really enjoy using this moisturizer both morning and night, though I primarily use it at night since I’m still enjoying the Versed Dew Point Moisturizing Gel-Cream as my morning moisturizer.

Team Player

Since I’ve used this moisturizer in my morning and night time skincare routines, I can confidently say that it is an excellent team player! On the rare mornings that I use it, I’ve found that it layers well with my skincare products and both sunscreen and makeup apply beautifully over it.

My night time skincare routine has been quite varied recently, but this moisturizer layers well with every type of product I’ve paired with it. I’m even able to mix my Good Molecules Vitamin C Booster Powder with it and it still applies smoothly without ever pilling up.


I briefly touched on the Derma E Advanced Peptides & Collagen Moisturizer ingredients in the intro, but there are so many more to discuss! While ingredients don’t tell the whole story for any given skincare product, they are the most important thing to consider when deciding which products to purchase. Let’s start with the full list of all 30 ingredients:

Water, Glycerin, Macadamia Ternifolia (Macadamia) Seed Oil, Caprylic/Capric Triglyceride, Stearic Acid, Acetyl Hexapeptide-8, Cetyl Alcohol, Glyceryl Stearate Citrate, Glyceryl Stearate, Ethylhexylglycerin, Dimethicone, Phenoxyethanol, Aesculus Hippocastanum (Horse Chestnut) Seed Extract, Camellia Sinensis (Green Tea) Leaf Extract, Chamomilla Recutita (Matricaria) Flower, Hamamelis Virginiana (Witch Hazel) Bark/Leaf Extract, Tocopheryl Acetate, Xanthan Gum, Simmondsia Chinensis (Jojoba) Seed Oil, Lavandula Hybrida Oil, Panthenol, Allantoin, Potassium Sorbate, Palmitoyl Tripeptide-38, Pinus Pinaster (Pycnogenol®) Bark Extract, Hydroxypropyl Cyclodextrin, Sodium Hydroxide, Acacia Seyal Gum Extract (Plant Derived Collagen), Retinyl Palmitate, Ascorbyl Palmitate

Like most skincare products I’ve reviewed, there are good, bad, and neutral ingredients in this formula. Fortunately, sixteen of the ingredients are good ones that provide actual benefits to the skin. There are only two that are potentially harmful, and the rest are neutral ingredients that support the formula. First let’s go over the good stuff (please note that my primary resources for ingredient information are INCI Decoder and Paula’s Choice Ingredient Dictionary)!

  • Glycerin
    • Natural moisturizer
  • Macadamia Ternifolia (Macadamia) Seed Oil
    • Rich in antioxidants
    • Emollient
  • Acetyl Hexapeptide-8
    • Famous peptide a.k.a. Argireline or “botox in a jar”
    • Smooths wrinkles
    • Moisturizes skin
  • Aesculus Hippocastanum (Horse Chestnut) Seed Extract
    • Anti-inflammatory
    • Wound-healing
  • Camellia Sinensis (Green Tea) Leaf Extract
    • Antioxidant
    • Anti-inflammatory
  • Chamomilla Recutita (Matricaria) Flower
    • Antioxidant
    • Potent skin-soothing property
    • May aggravate skin that is sensitive to plants in the daisy family
  • Tocopheryl Acetate (most common version of vitamin E)
    • Antioxidant
    • Skin-strengthening
  • Simmondsia Chinensis (Jojoba) Seed Oil
    • Wax ester that stays on the skin surface to moisturize and make skin soft
  • Panthenol (Provitamin B5)
    • Moisturizer
    • Humectant
  • Allantoin
    • Skin soothing and conditioning agent
  • Palmitoyl Tripeptide-38
    • Another well-known peptide a.k.a. Matrixyl synthe’6
    • Boosts production of major components of the extracellular matrix (including collagen)
    • Decreases wrinkles, particularly in the forehead and crow’s feet
  • Pinus Pinaster (Pycnogenol®) Bark Extract
    • Contains potent antioxidants
    • Increases skin hydration and elasticity
    • May increase synthesis of extracellular matrix molecules, hyaluronic acid and collagen
  • Hydroxypropyl Cyclodextrin
    • Moisturizer
    • Has a lifting effect on skin
  • Acacia Seyal Gum Extract (Plant Derived Collagen)
    • Moisturizer
    • Humectant
  • Retinyl Palmitate
    • Retinoid (retinol paired with palmitic acid)
    • Must be converted to retinoic acid by the skin to be effective
    • Antioxidant
  • Ascorbyl Palmitate
    • Stable form of vitamin C
    • Antioxidant

That’s quite the list, right? I’m impressed by how many great ingredients Derma E was able to pack into this product. I do wish that more of these ingredients were closer to the top (higher concentrations), but it’s possible that some of them are more effective at lower concentrations. 

I was especially excited to see the multi-peptides in this product. I’ve never used a product with Acetyl Hexapeptide-8 (Argireline) or Palmitoyl Tripeptide-38 (Matrixyl synthe’6). These seem to be even more effective for anti-aging than other peptides I’ve researched in other products!

While it does moisturize the skin, I’m a bit confused about the Acacia Seyal Gum Extract (collagen) being included in this product. I think Derma E may have included it so they could include the word “collagen” in the product’s name. This isn’t an uncommon practice since people associate collagen with youthful skin. The thing is, applying collagen topically doesn’t translate to more collagen within the skin. The peptides and Pinus Pinaster (Pycnogenol®) Bark Extract, however, do increase production of collagen in the skin.

Now for the “bad” ingredients in this moisturizer. The first one is controversial because many people swear by it: witch hazel. Witch hazel has antioxidant and soothing properties, but one of the antioxidants in it (tannin) can also make it sensitizing. Additionally, witch hazel contains a fragrance called “eugenol” which may be sensitizing. The only other ingredient that may be problematic for some people is Lavandula Hybrida Oil which is an essential oil that can be sensitizing.

The remaining “neutral” ingredients are all quite innocuous: things like emollients and thickeners. There is one ingredient that I view as neutral that some people might want to avoid. This product contains dimethicone, which is a common silicone used to make skin feel smooth. I don’t personally feel that dimethicone affects the performance of the other ingredients or harms the skin.


If you read through the “other product details” section, you probably noticed that there’s quite a large price difference when purchasing from Amazon instead of from On Amazon, Derma E Advanced Peptides & Collagen Moisturizer is only $21.00 ($10.50/ounce). If purchasing this moisturizer directly from Derma E, it is $35.00 ($17.50/ounce)!

I’m going to be reviewing Amazon’s price for this product since I don’t think many people would choose to pay so much more to purchase from Derma E (unless Derma E has a good sale going, which they sometimes do!). This is a really good quality moisturizer with unusual and effective anti-aging ingredients, so I think $21.00 is a very fair price for it.

I’m really glad that I stumbled on Derma E Advanced Peptides & Collagen Moisturizer! Despite the flowery scent, I really enjoy using it. This moisturizer is a great finishing touch on my skincare routine every night. It makes my skin feel great and I’m happy knowing that I’m applying so many anti-aging ingredients that will help preserve my youthfulness.

Even though this moisturizer was formulated with anti-aging in mind, I think it would be beneficial for all age groups. As far as skin types go, it would probably work best for normal to oily skin types. I have combination skin and it’s perfect for me, but I feel as though it may not be quite hydrating enough for someone with dry skin. Those with sensitive skin may also need to skip this one due to the strong fragrance.

Derma E makes several different moisturizers, but this is the first one I’ve ever tried. Have you tried any Derma E moisturizers? Or are there other products from Derma E that you’ve enjoyed? Please let me know in the comments below!


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